The Seandel Laboratory

Department of Surgery
Weill Cornell Medical College
New York, NY

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Publications


Arnold, K., Sarkar, A., Yram, M.A., Polo, J.M., Bronson, R., Sengupta, S., Seandel, M., Geijsen, N. & Hochedlinger, K. Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of mice. Cell Stem Cell 9, 317-329 (2011).


Seandel, M. & Eggan, K. Stem Cells: Doing Some Heavy Lifting at ISSCR 2011. Cell Stem Cell 9, 311-315 (2011).

Seandel, M. & Rafii, S. Reproductive biology: In vitro sperm maturation. Nature 471, 453-455 (2011). 


Hobbs RM, Seandel M, Falciatori I, Rafii S, Pandolfi PP.
Plzf regulates germline progenitor self renewal by opposing mTORC1: Cell 2010 142 (3): 468-479. 


Butler JM, Nolan DJ, Vertes EL, Varnum-Finney B, Kobayashi H, Hooper AT, Seandel M, Shido K, White IA, Kobayashi M, Witte L, May C, Shawber C, Kimura Y, Kitajewski J, Rosenwaks Z, Bernstein ID, Rafii S. Endothelial Cells Are Essential for the Self-Renewal and Repopulation of Notch-Dependent Hematopoietic Stem Cells. Cell Stem Cell 2010; 6:251-64.

 

James D, Nam HS, Seandel M, Nolan D, Janovitz T, Tomishima M, Studer L, Lee G, Lyden D, Benezra R, Zaninovic N, Rosenwaks Z, Rabbany SY, Rafii S. Expansion and maintenance of human embryonic stem cell-derived endothelial cells by TGFbeta inhibition is Id1 dependent. Nat Biotechnol 2010; 28:161-6.
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Seandel M, Butler JM, Kobayashi H, Hooper AT, White IA, Zhang F, Vertes EL, Kobayashi M, Zhang Y, Shmelkov SV, Hackett NR, Rabbany S, Boyer JL, Rafii S. Generation of a functional and durable vascular niche by the adenoviral E4ORF1 gene. Proc Natl Acad Sci U S A 2008; 105:19288-93.
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James D, Seandel M, Rafii S. Endothelial ontogeny from embryo to adult: Role of cytokine signaling pathways. In: Rajasekhar VK, Vemuri MC, Mohan C, eds. Regulatory Networks in Stem Cells. New York: Springer, 2009.
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Seandel M, Falciatori I, Shmelkov SV, Kim J, James D, Rafii S. Niche players: spermatogonial progenitors marked by GPR125. Cell Cycle 2008; 7:135-40.
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Seandel M, Hooper AT, Rafii S. Contribution of Stem Cells to the Angiogenic Process. In: Folkman J, Figg W, eds. Angiogenesis:  An integrative approach from science to medicine. New York: Springer, 2008:239-48.
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Seandel M, Butler J, Lyden D, Rafii S. A catalytic role for proangiogenic marrow-derived cells in tumor neovascularization. Cancer Cell 2008; 13:181-3.
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Kim J, Seandel M, Falciatori I, Wen D, Rafii S. CD34+ testicular stromal cells support long-term expansion of embryonic and adult stem and progenitor cells. Stem Cells 2008; 26:2516-22.
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Seandel M, James D, Shmelkov SV, Falciatori I, Kim J, Chavala S, Scherr DS, Zhang F, Torres R, Gale NW, Yancopoulos GD, Murphy A, Valenzuela DM, Hobbs RM, Pandolfi PP, Rafii S. Generation of functional multipotent adult stem cells from GPR125+ germline progenitors. Nature 2007; 449:346-50.
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Zijlstra A, Seandel M, Kupriyanova TA, Partridge JJ, Madsen MA, Hahn-Dantona EA, Quigley JP, Deryugina EI. Proangiogenic role of neutrophil-like inflammatory heterophils during neovascularization induced by growth factors and human tumor cells. Blood 2006; 107:317-27.
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Seandel M, Shia J, Linkov I, Maki RG, Antonescu CR, Dupont J. The activity of sunitinib against gastrointestinal stromal tumor seems to be distinct from its antiangiogenic effects. Clin Cancer Res 2006; 12:6203-4.
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Zijlstra A, Aimes RT, Zhu D, Regazzoni K, Kupriyanova T, Seandel M, Deryugina EI, Quigley JP. Collagenolysis-dependent angiogenesis mediated by matrix metalloproteinase-13 (collagenase-3). J Biol Chem 2004; 279:27633-45.
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Seandel M, Noack-Kunnmann K, Zhu D, Aimes RT, Quigley JP. Growth factor-induced angiogenesis in vivo requires specific cleavage of fibrillar type I collagen. Blood 2001; 97:2323-32.
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